Natural product inhibitors of ocular angiogenesis
نویسندگان
چکیده
منابع مشابه
Vasoinhibins: novel inhibitors of ocular angiogenesis.
Disruption of the quiescent state of blood vessels in the retina leads to aberrant vasopermeability and angiogenesis, the major causes of vision loss in diabetic retinopathy. Prolactin is expressed throughout the retina, where it is proteolytically cleaved to vasoinhibins, a family of peptides (including the 16-kDa fragment of prolactin) with potent antiangiogenic, vasoconstrictive, and antivas...
متن کاملNatural products as angiogenesis inhibitors.
Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation, or atherosclerosis. Angiogenesis inhibitors are able to interfere with various steps of angiogenesis, like...
متن کاملZebrafish Bioassay-Guided Natural Product Discovery: Isolation of Angiogenesis Inhibitors from East African Medicinal Plants
Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. The identification of lead compounds of natural origin would benefit from therapeutically relevant bioassays capable of facilitating the isolation of bioactive molecules from multi-constituent extracts. Towards this end, we developed an in vivo bioassay-guided isolation approach f...
متن کاملNatural product family 18 chitinase inhibitors.
Ole Andreas Andersen received hisM.Sc and Ph.D from theUniversity of Tromsø, Norway, in 1998 and 2003, respectively. His Ph.Dwork was supervised by Prof. Edward Hough and comprised crystallographic and biochemical studies on human phenylalanine hydroxylase. Andersen had a postdoctoral fellowship for one year at The Norwegian Structural Biology Centre in Tromsø under the supervision of Prof. Arn...
متن کاملOcular Angiogenesis
1Department of Health Informatics, Federal University of São Paulo, Paulista School of Medicine, 04023-062 São Paulo, SP, Brazil 2Department of Biochemistry, Federal University of São Paulo, Paulista School of Medicine, 04039-032 São Paulo, SP, Brazil 3Department of Biochemistry, University of São Paulo, 05508-000 São Paulo, SP, Brazil 4Department of Ophthalmology, Federal University of São Pau...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2014
ISSN: 0014-4835
DOI: 10.1016/j.exer.2014.10.002